The self emulsified drug delivery system (SEDDS) is characteristic property of water-in-oil emulsion formulation which gets emulsified by little motility in GIT. The mixture of surfactant and co-surfactant forms stable emulsion which have minimal free energy as it forms with minimal energy of emulsification. The excipients were selected with drug solubility and the flow ability of emulsion with the basic criteria. These were selected by ternary phase diagram plot with criteria of easy dispersibility, stability and transparency after addition in water (outer phase). Particle size analysis showed sizes of the resultant microspheres that were approximately 100 µm or less. SEDDS have high loading efficiencies due to its excipients and have efficient drug release profile. The maximum drug gets released in early 10 min. which cause efficient formulation of low bio-available drug.
Loading....